报告题目：Synaptic Plasticity and Its Clinical Implications in Neuropathic Pain
报 告 人：潘惠麟 教授（The University of Texas MD Anderson Cancer Center）
主 持 人：徐广银 教授
Dr. Hui-Lin Pan received his medical and graduate degrees (Neurobiology/Cardiology) from Tongji Medical University in Wuhan. He conducted his postdoctoral research fellowship at University of California, Davis, studying cardiovascular physiology and primary sensory nerves innervating the heart and abdominal visceral organs. His subsequent faculty appointments in Neuroscience and Anesthesiology were at Wake Forest University School of Medicine and Penn State University College of Medicine.
Dr. Pan currently holds the position as Helen T. Hawkins Distinguished Professor and Deputy Division Head for Research in Division of Anesthesiology and Critical Care at The University of Texas MD Anderson Cancer Center in Houston. His major research interest includes epigenetic and synaptic mechanisms of neuropathic pain, autonomic regulation in hypertension, and pharmacological signaling of G protein-coupled receptors. His research programs have been continuously funded by NIH for >20 years. He has published more than 180 original studies in peer-reviewed journals including Circulation, Cell Rep, J Biol Chem, J Physiol, J Neurosci, Neuron, Nat Neurosci.
1. Zhou HY, Chen SR, Chen H, Pan HL. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci 2010;30:4460-4466.
2. Li DP, Byun HS, Pan HL. Switch to GluR2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. J Neurosci 2012;32:372-380.
3. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol 2014;592:215-227.
4. Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition. Nature Neurosci 2015;18:1746-1755.
5. Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL. Chloride homeostasis critically regulates synaptic NMDA receptor activity in neuropathic pain. Cell Rep 2016;15:1376-1383